[This is how Sherlock copes. He lashes out at people. In most instances, this would be the point where John would just step out to the grocery or the pub to let his friend work through some of it on his own. Unfortunately, that isn't really an option here. He sighs and glances up toward the cloudy sky for a moment, asking for patience. The initial anger at Sherlock has burned out.]

Sherlock, you're a human being. Your mind and everything about you is amazing, you think differently, you're cleverer than anyone else I know. You are brilliant.

But at a fundamental level, you have a brain that physically functions like other brains. And if there's something physically influencing the chemical balance or structure of your brain, it doesn't matter what mental barriers and defenses you have. This is physical. And last I checked, you haven't got titanium shielding in that head of yours.